急性进展性脑梗死中凝血功能检测的作用

Clinical significance of coagulation function in acute progressive cerebral infarction

目的探讨凝血功能检测在急性进展性脑梗死中的作用。方法选择78例发病48h以内的急性期脑梗死患者,分为进展组22例、稳定组56例,均为SSS评分系统及颅脑CT确诊。所有入选病例均于发病48h内采血2.7ml,检测凝血功能。结果进展组纤维蛋白原(3.6±0.6)g/L,稳定组纤维蛋白原(2.5±0.6)g/L,2组比较差异有统计学意义(P<0.05)。而2组凝血酶原时间(PT)、凝血酶原活动度(PA)、部分凝血活酶时间(APTT)、凝血酶时间(TT)差异无统计学意义(P<0.05)。结论发病后高纤维蛋白原水平为急性进展性脑梗死的危险因素。

Objective To investigate the clinical significance of coagulation function in acute progressive cerebral infarction（APCI）.Methods 78 patients with cerebral infarction who were admitted to our hospital within 48 hours after acute onset were divided into two groups,progressive group（n=22）and stable group（n=56）.All the patients were matched with diagnosis by clinical standards referred to the fourth national cerebrovascular diseases meeting in 1995（SSS Scoring System）and were confirmed by computerized tomogramphy （CT）. The patients＇blood （2.7ml） was taken to examine the coagulation function. Results The mean fibrinogen （3.6 ± 0.6 g/L） in progressive group was significantly higher than that （2.5 ± 0.6 g/L） in stable group （ P 〈 0.05 ）. There were no significance differences in prothrombin time （ PT）, prothrombin activity （PA）, activated partial thromboplastin time （APTT） and thrombin time （TT） between the two groups. Conclusion The high levels of fibrinogen are one of the risk factors in acute progressive cerebral infarction.