摘要
雷公藤甲素是从中药雷公藤中提取的环氧化二萜内酯化合物,是雷公藤发挥抗肿瘤作用的主要活性成分,具有广谱、高效抗肿瘤作用。作者从雷公藤甲素诱导肿瘤细胞凋亡、干预细胞周期、抑制新生血管形成等方面,对其抗肿瘤作用机制研究进展进行了综述。
Triptolide, an epoxidated diterpene lactone compound separated from a traditional Chinese medicine, Tripterygium wilfordiiHook, f (TWHF), is responsible for the anti-tumor activity of TWHF with broad spectrum and high performance. The antitumor mechanism of triptolide locates in many fields, such as inducing apoptosis of tumor cell, interfering in the cell cycle, and suppressing angiogeneis. The advance in the anti-tumor mechanism of triptolide is described in the following review.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2009年第16期2024-2026,共3页
China Journal of Chinese Materia Medica
基金
重大新药创制科技重大专项项目(2008ZX09305-003)
北京市自然科学基金项目(7092079)