甘蔗烷醇对鹌鹑高脂血症动脉粥样硬化模型的影响研究

Study on sugarcane alkane alcohol to quail hyperlipidemia and atherosclerosis model

目的:研究甘蔗烷醇提取物对鹌鹑高脂血症动脉粥样硬化模型的药理作用。方法:用外源性胆固醇和高脂饲料复制鹌鹑高血脂模型,并诱发动物的动脉粥样硬化(AS)模型,观察甘蔗烷醇对造模动物血脂水平的影响,对造模动物动脉粥样斑块的形成、冠状血管及血管内膜病变的影响。结果:甘蔗烷醇30,15,7.5 mg.kg-1可降低鹌鹑高血脂模型血清中TC,TG,LDL-C水平,抑制主动脉内膜、头臂动脉内膜泡沫细胞的增殖。结论:甘蔗烷醇通过调整血脂,对高脂血症和高血脂诱发的动脉粥样硬化动物模型具有良好的药理作用。

Objective： To study on pharmacologic actions on quail hyperlipidemia and atherosclerosis model. Method： To duplicate quail hyperlipidemia model by ectogenesis cholesterol and high fat forage, induce to atherosclerosis model, observe influence of sugarcane alkane alcohol to model animals＇blood fat level, formation of atherosclerosis plaque, pathological changes of coronary vessels and vascular intimal. Result： TC, TG, LDL-C level in blood serum of quail hyperlipidemia markedly decreased after administered sugarcane alkane alcohol by dose of 30, 15, 7.5 mg · kg^-1, proliferation of aorta and brachiocephalic artery tunica intima foam cells was suppressed. Conclusion： Sugarcane alkane alcohol has satisfactory pharmacologic actions on hyperlipidemia and atherosclerosis animal model by regulating blood fat.