窄谱中波紫外线治疗36例泛发性白癜风的临床疗效观察

Observation of the efficacy of narrow-band Ultraviolet B phototherapy in vitiligo

目的:观察窄谱中波紫外线(NB-UVB)照射治疗白癜风的临床疗效及其影响因素。方法:将72例白癜风患者随机分为2组,治疗组36例,采用口服中药白癜风1号颗粒与NB-UVB全身照射,间隔2日照射1次;对照组36例,采用口服中药白癜风1号颗粒,外用卤米松软膏。结果:3个月时,治疗组总有效率47.22%,对照组19.44%;6个月时,治疗组总有效率61.11%,对照组25.00%,2组比较,差异有显著性意义(P<0.05)。结论:NB-UVB照射治疗白癜风安全有效且不良反应小,其疗效与患者的皮损面积、发病部位、病程及治疗疗程有关。

Objective：To observe the efficacy and influence factor of narrow-band ultraviolet B （NB-UVB） in the treatment of patients with vitiligo. Methods ：72 patients with vitiligo were divided randomly into two groups. 36 patients were treated with NB-UVB and Vitiligo 1 granule in study group and 36 patients with Vitiligo 1 granule for internal use and Halometasone cream for external use in control group. Results：On 3 months after the treatment,in study group, the effective rate was 47.22% ;in control group, the effective rate was 19.44%. On 6 months after the treatment,in study group,the effective rate was 61.11% ;in control group,the effective rate was 25. 00%. The effective rate in study group was higher than that in control group, which was siganificantly difference （ P 〈 0.05）. Conclusions：NB-UVB is effective with few adverse effects in the treatment of vitiligo. The efficacy was related to skin eruption areas, body part, course of disease and treatment.