初诊重度2-型糖尿病(T_2DM)应用门冬胰岛素30疗效观察

Clinical Investigation on Insulin Aspart 30 in Firstly Diagnosed Severe Type 2 Mellitus Patients

目的:观察胰岛素治疗初诊重度2-型糖尿病(T2DM)疗效。方法:初诊重度T2DM50例,随机分为胰岛素治疗组(n=26)和口服磺脲类治疗组(n=24)两组,观察治疗前和治疗6个月后各组的FBG、P2hBG、HbA1c、空腹C肽、餐后2hC肽。结果:治疗6个月后胰岛素治疗组的FBG、P2hBG、HbA1c、空腹C肽、餐后2hC肽变化明显优于口服磺脲类治疗组(P<0.05),轻度低血糖发生率两组大体相当,重度低血糖发生率胰岛素治疗组明显低于口服磺脲类治疗组。结论:胰岛素是控制疗初诊重度2-型糖尿病血糖的有效方法。

Objective ： Clinical investigation on therapy effectiveness of insulin in firstly diagnosed severe type 2 diabetes mellitus （T2DM） patients. Methods： 50 firstly diagnosed severe T2DM patients were randomly divided into two groups, insulin aspart 30 group （n=26） and oral suffonylureas drugs group （n=24）. Pre- and post-treatment of FBG,P2hBG,HbAlle,fasting peptide C,postprandial peptide C of each group were measured after 6 months treatment. Results： Levels of FBG,P2hBG,HbAlc,fasting peptide C,postprandial peptide C in the insulin group are significantly ameliorated than the suffonylureas group （P〈0.05）.Mild hypoglycemia incidence is similar between two groups, but severe hypoglycemia incidence in insulin group is significantly lower than in sulfonylureas group. Conclusion ： Insulin aspart 30 can effectively reduce blood glucose in firstly diagnosed severe T2DM patients.