皮下注射低分子肝素钙局部按压时间对皮下出血影响的临床研究

Clinical Study of the Relationship between Local Pressing Duration after Low Molecular Weight Heparin Subcutaneous Injection and Subcutaneous Hemorrhage

目的:探讨皮下注射低分子肝素钙局部按压时间与皮下出血发生率的关系,同时找出有效的按压时间,以降低皮下出血的发生率。方法:选择急性脑梗塞病人需皮下注射低分子肝素钙的患者104例,随机分为3组,每组按压时间分别为2min、3min、5min。观察皮下出血的例次及出血情况。结果:皮下注射低分子肝素钙不同按压时间与皮下出血存在统计学差异(P<0.01),且3min与5min组出血率比较,差异具有明显统计学意义(P<0.01),而3min与2min组无统计学差异。结论:皮下注射低分子肝素钙按压5min可以有效降低皮下出血发生率。

Objective ： To investigate the Relationship among the local pressing time the incidence and the size of subcutaneous hemorrhage, and find an optimum pressing time in order to reduce the incidence and the size of subcutaneous hemorrhage after the subcutaneous injection of low molecular weight heparin （LMWH）. Methods ： The patients who were received LMWH were divided into three groups （1, 2, 3 minutes） by random, the incidence and the size of subcutaneous hemorrhage were measured. Results ： The incidence of subcutaneous hemorrhage and the occurrence of large size were significantly different between 3-minute group and 5-minute group, while there were no difference between 2-minute and 3-minute group. Conclusion： Pressing for five minutes can effectively reduce the incidence and the size of subcutaneous hemorrhage resulted from subcutaneous injection of LMWH.