预防性治疗儿童泌尿道感染的试验研究

Clincal Study of Prophylatic Treatment in Childhood Urinary Tract Infection

目的抗生素预防泌尿系感染复发的疗效以及传统中药对其影响。方法58例患儿随机分别进行抗生素加中药治疗(治疗1组)、单用抗生素治疗(治疗2组)和观察(对照组)。评估各组在预防治疗期间、预防治疗后1年的复发率的差异。结果治疗组与对照组在预防治疗期间、治疗后1年复发率的差异均有显著性意义。在按有无既往感染史分类的前提下同样有显著性意义。不同治疗组之间在预防治疗期间、预防治疗后1年复发率上的差异均无显著性意义。结论长期低剂量的抗生素治疗可以有效地预防感染的复发。传统中药对其作用影响不大。

Objective To determine the efficacy of long-term low-dosage antibiotics in preventing recurrent urinary-tract infection and the effect of traditional chinese medicine on it.Materials And Methods Fifty-eight children with normal urinary tracts were randomized into prophylactic antibiotics plus chinese medicine,single antibiotics and observation.To estimate the recurrence rate during and after prophylaxis and recurrence rate in one year.Results The differences between the study group and the control group in the recurrence rate during prophylactic treatment and recurrence rate in one year were significant. When the previous history of infection was taken into account , the ob- vious differences in recurrence after prophylactic treatment in two＂ groups were significant. There were no differences in the recurrence rates during and after prophylaxis and in the recurrence rates in one year between antibiotics plus chinese medicine and single antibiotics. Conclusion Long -tern low - dosage antibiotics may prevent further infection of normal urinary tract. Traditional chinese medicine may have less effect on the role of antibiotics.