胰腺实性-假乳头状瘤的临床病理观察

Pathological Features of Solid-pseudopapillary Neoplasm of Pancreas

目的对原发于胰腺实性-假乳头状瘤(solid-pseudopapillary neoplasm,SPN)进行临床与病理观察,认识其临床病理特征,诊断与鉴别诊断。方法观察了3例胰腺实性-假乳头状瘤的光镜形态,采用Envi-sion法免疫组化标记AAT、Vimentin、Ki-67、CD10等并结合文献复习其生物学行为。结果光学显微镜下:肿瘤细胞形态大多一致,排列呈实性、片状,或以血管为中心的乳头状排列,免疫组化结果一致:AAT、Vimentin、CD10均阳性,Ki-67<3%。结论胰腺实性-假乳头状瘤诊断要结合临床资料,病理组织学形态以及免疫组化结果,该肿瘤预后较好,但有一定的潜在危险性,随访重要。

Objective To explore the pathologic features,diagnosis and differential diagnosis of primary solid-pseudopapillary neoplasm（SPN） of the pancreas.Methods Three SPN cases were retrospectively analyzed by morphology observation combined with immunohistochemisty staining by AAT,vimentin,Ki-67 and CD10 antibodies.Results Microscopically SPN tumor cells showed animous similar type,with two cellular arrangements：solid and papillary,the pseudopapillary area had fibrovascular stalks and a partially rosette-like pattern. AAT,Vimentin and CDIO staining showed positive expression in all cases, while ki -67 expression was less than 3 %. Conclusion SPN is a rare neoplasm, its diagnosis should be based on the combination of clinical presentations, pathological features and immunohistochemistry results. Although this tumor has better prognosis, it has an indolent growth pattern, therefore follow- up will be very crucial.