肝硬化门脉高压症患者血浆降钙素基因相关肽检测的临床意义

The clinical significance of plasma calcitonin gene-related peptide measurement in patients with cirrhosis and portal hypertension

目的研究肝硬化门脉高压症患者血浆降钙素基因相关肽(CGRP)检测的临床意义。方法62例肝硬化患者,其中男42例,女20例,按Child-Pugh分级标准分为3组,应用放免法测定血浆降钙素基因相关肽(CGRP)。结果各组血浆CGRP水平为Child-Pugh C>Child-Pugh B>Child-Pugh A,在肝功能不同的患者之间Child-Pugh C级患者的检测结果显著于Child-Pugh A级和Child-Pugh B级患者(P<0.01)。结论血浆CGRP水平是反映肝硬化程度的一个有效指标,升高的血浆CGRP水平在肝硬化门静脉高压症的发病过程中起着重要的作用。

Objective To investigate the clinical significance of plasma calcitonin gene-related peptide（CGRP） measurement in patients with cirrhosis and portal hypertension. Methods Totally 62 inpatients（42 males and 20 females）from January 2007 to April 2008 were grouped according to Child-Puch grading standard. Plasma level of CGRP was measured with radioimmunoassay（RIA）. Results The plasma CGRP level of Puch C group was the highest,followed by that of Puch B group and Puch A group. The differences were statistically significant（P〈0.01）. Conclusion Plasma CGRP level is a useful marker for cirrhosis severity; and high plasma level of CGRP plays an important role in the process of cirrhosis and portal hypertension.