高敏CRP水平与非酒精性脂肪性肝炎的相关性研究

Research on association of hs-CRP and nonalchonic sulfatide hepatitis

目的探讨高敏CRP(hs-CRP)水平与非酒精性脂肪性肝炎(NASH)的相关性。方法研究47例经肝活检病理诊断为非酒精性脂肪性肝病(NAFLD)的患者(19例单纯性脂肪肝患者、28例NASH患者),检测所有受试者的血清hs-CRP水平。结果与单纯性脂肪肝患者相比,NASH患者的血清hs-CRP水平显著升高(P=0.004 8)。进一步分析NASH合并进展性肝纤维化患者的血清hs-CRP水平,结果提示其显著高于肝纤维化程度较轻患者(P=0.038 4)。校正受试者的年龄、性别、高密度脂蛋白胆固醇、甘油三酯、低密度脂蛋白胆固醇等多项指标,各组之间差异有统计学意义。结论该研究首次证实了NASH患者的血清hs-CRP水平持续显著高于单纯性脂肪肝患者,提示hs-CRP不仅可以区分NASH和非进展性脂肪性肝病,而且在一定程度上,能够反映NASH患者肝纤维化的病变程度。

Objective To investigate the correlation of high sensitivity C reactive protein（hs- CRP） and nonalchonic sulfatide hepatitis（NASH）. Methods A total of 47 patients with nonalchonic fatty liver disease（NAFLD） were divided into simple hepatic adipose group（n= 19） and NASH group （n=28）. Serum level of hs-CRP was measured in all subjects. Results As compared with that of simple hepatic adipose group,the serum level of hs-CRP was significantly higher in NASH group（P=0. 0048）. The serum level of hs-CRP was significantly higher in patients with NASH and advanced fibrosis than that in patients with NASH and slight fibrosis（P=0. 0384）. Even after rectification of multiple indices（including age, gender, HDL-cholesterol, triglyeride and LDL-cholesterol）, there were significant differences among several groups. Conclusion This is the first report that NASH patients keep significantly higher serum level of hs-CRP compared with patients of simple hepatic adipose. The results show that hs-CRP not only distinguishes NASH and non-progressive fatty liver diseases,but also reflects the severity of hepatic fibrosis in NASH patients.