凋亡抑制蛋白XIAP在舌鳞癌组织中表达的研究

Expression and Clinical Significance of Antiapoptosis Gene XIAP in Tongue Squamous Cell Carcinoma

目的:研究XIAP在舌鳞癌组织中的表达情况及其与舌鳞癌临床病理特征的关系。方法:采用免疫组织化学SP法检测舌鳞癌组织(36例)以及癌旁正常舌粘膜组织(20例)中XIAP蛋白的表达,并分析其与舌鳞癌临床病理特征的关系。结果:XIAP在舌鳞癌组织中表达阳性率为86.1%,在癌旁正常粘膜组织中阳性率为35%,肿瘤组织中XIAP蛋白阳性率明显高于正常粘膜;不同病理分级及临床分期病例XIAP阳性表达差异无显著性。结论:XIAP蛋白的高表达与舌鳞癌的发生有相关性,可能在舌鳞癌的发生、发展过程中有重要作用。

Objective： To explore the effects of XIAP expression on carcinogenesis and clinical significance of this expression in tongue squamous cell carcinoma. Methods： The expression of XIAP was detected by SP immunohistochemistry in 20 cases of normal tissues and 36 cases of tongue squamous cell carcinoma .The relationship between the protein expression and clinicoathological features was analyzed. Results： Of the 36 patients with tongue squamous cell carcinoma 31 （86.1%） were found to have positive XIAP expression, which was much higher than that in normal tissues. XIAP expression was not related to the tumor size, tumor differentiation, lymph node metastasis and clinical classification （P〉0.05）. Conclusions： XIAP expression was higher in tongue squamous cell carcinoma than that in normal tissues, suggesting that XIAP maybe plays a role to some extent in the development of tongue squamous cell carcinoma.