稀土元素的肝脏蓄积性及毒性危害

Accumulation and Toxicity of Rare Earth Elements in Liver

综合论述了稀土元素在机体肝脏的蓄积性及其毒性效应,分析了稀土农业应用对生态环境和人群健康的危害。稀土元素被长期低剂量摄入,可在肝脏中蓄积,导致肝脏形态和病理组织变化、肝细胞损伤、肝代谢紊乱引起脂肪肝;高于2 mg.kg-1剂量的农用稀土(常乐)仍能通过胎盘屏障引起肝细胞和发育中的红细胞DNA损伤。

A comprehensive review is presented on accumulation and toxicity of rare earth dements in liver of human body, with stress on potential hazard of rare earth elements fertilizers used in agricultural production to the environment and health of the human hepatic system. Long-term intake of low dose rare earth elements may lead to accumulation in the hepatic tissue, leading to changes in the morphology hepatocyte and pathologic tissue, hepatocyte harm, shaped fatty liver because of metabolize, more than 2 mg · kg^-1 mixed rare earth （Changle） may cross placenta barrier and cause DNA damage of hepatocyte and developing erythrocyte of rat embryo.