摘要
目的探讨成人支气管哮喘β2-肾上腺受体(β2-AR)功能与BMI的相关性。方法选择我院门诊2007年12月至2009年1月确诊为支气管哮喘患者83例,依据严重程度进行分级,测定其体重指数(BMI)、血cAMP值,并分析两者的相关性。结果在支气管哮喘轻、中、重度持续组BMI分别为:(23.24±4.25)kg/m2、(25.25±3.25)kg/m2和(27.52±4.74)kg/m2;cAMP分别为:(23.49±5.99)umol/L、(14.34±4.43)umol/L和(11.08±3.72)umol/L,三组比较差异均有统计学意义,BMI与血cAMP呈线性关系,相关系数是r=-0.248(p<0.05)。结论支气管哮喘患者体重指数(BMI)与血cAMP值存在负相关。
Objective To explore if body mass index （BMI） is related to the function of β2-adrenergic receptor （β2-AR）in patients with asthma. Methods A total of 83 patients with asthma were studied. We analysed the relation of BMI and the function of β2- Adrenergic Receptor. Results The values of BMI were 23.24 ±4.25kg/m2, 25.25±3.25 kg/m2 and 27.52 ±4.74kg/m2 in mild, moderate,severe persistent group, respectively. The values of cAMP were 23.49±5.99umol/L,14.34±4.43 .umol/L and 11.08±3.72umol/ L, in mild,moderate,severe persistent group, respectively.Those were significant differences among three groups. The levels of BMI had negative correlation with cAMP. Conclusion BMI is related to the levels of cAMP in asthma.
出处
《医学信息》
2009年第9期1796-1797,共2页
Journal of Medical Information
基金
东莞市科技局基金资助(项目编号:2008105150244)
