缺氧诱导因子-1α在妊娠期肝内胆汁淤积症胎盘组织的表达及意义

Expression of Hypoxia Inducible Transcription Factors-1α in Placenta with Intrahepatic Cholestasis of Pregnancy

目的探讨缺氧诱导因子-1α(HIF-1α)在妊娠期肝内胆汁淤积症(ICP)胎盘组织的表达及其在ICP胎儿宫内缺氧中的意义。方法采用免役组织化学的方法检测18例ICP胎盘(其中重症组7例,轻症组11例)和18例正常妊娠胎盘的HIF-1α的表达。结果ICP组胎盘组织的HIF-1α的表达明显高于正常妊娠组(p<0.05),且其表达与ICP分级之间存在等级相关(r=0.448,p<0.01)。结论ICP胎盘-胎儿系统存在缺氧,缺氧导致的HIF-1α的升高对胎儿适应缺氧有重要意义,当缺氧发生失代偿以及在宫缩等因素影响下加重时,在慢性缺氧的基础上并发急性缺氧可能是导致胎儿不良结局的原因。HIF-1α可能是揭示ICP发病及造成胎儿不良结局的机制的重要因子。

Objective To investigate the expression of Hypoxia-inducible factor-lalpha （Hif-1α） in placenta and it＇s role in the mechanism of fetal asphyxia with Intrahepatic Cholestasis of Pregnancy（ICP）. Methods The expression of Hif-1αin 18 placentas from pregnancy women with ICP （7 severe ICP and 11 light ICP） and 18 placentas from normal pregancy was detected by immunohistochemistry. Results The expression level of Hif-1α in ICP group was significant higher than that in contral group（p〈0.05）, furthermore, it had a positive correlation with the ICP level.（r=0.048,p〈0.01）.Conclusions It do exist that ICP can induce fetalplacental anoxia.The high expression of Hif-1α may be one inportant factor of the hypoxia pathogenesis and play an essential role in the fetal asphyxia with ICP.