左卡尼汀在特发性弱精子症患者中的水平测定

The level of L-carnitine in seminal plasma of patients with idiopathic asthenospermia

目的探讨特发性弱精子症患者中左卡尼汀水平与精子活力的关系。方法实验组：特发性弱精子症50例，对照组：有致孕史男性10例。采用高效液相色谱法测定精浆左卡尼汀水平，并检测精液参数（精液量、精子密度、精子前向运动百分率）。结果两组精子密度、精子前向运动百分率差异有统计学意义（P〈0．01）；左卡尼汀水平有显著性差异。结论特发性弱精子症患者的左卡尼汀水平明显降低，与精子活力低密切相关，提示左卡尼汀治疗特发性弱精子症为有效的治疗方法。

Objective To study the relationship between sperm activity and the level of L-carnitine in seminal plasma of patients with idiopathic asthenospermia by HPLC. Methods Experimental group： idiopathic asthenospcrmia 50 cases, and the control group： male with pregnancy history 10 cases. The semen parameters （volume, sperm density, viability, motility） , and L-carnitine level in seminal plasma were detected with high performance liquid chromatography method. Results There were significant difference between A and B group about sperm density and the percentage of progressive motile spermatozoa, and the level of L-carnitine（ P 〈0.01 ）. Conclusions The decrease of L-carnitine level in patients with idiopathic asthenospermia, is closely related to the low sperm motility, which shows that L-carnitine can be used to treat idiopathic asthenospermia effectively.