264例慢性重型肝炎患者不同治疗措施的疗效观察

Therapeutic Effect of Different Therapeutic Measures on 264 Cases With Chronic Severe Hepatitis

目的:探讨慢性重型肝炎的不同治疗措施与预后之间的关系。方法:回顾性调查我院感染科住院的264例慢性重型肝炎患者,分别统计分析抗病毒治疗、免疫调节治疗和血浆置换治疗对患者预后的影响。结果:抗病毒治疗可显著提高早期、中期患者治疗有效率(P<0.05);免疫调节治疗在早期及中期患者预后优于对照组(P<0.05);血浆置换治疗可改善中期患者预后(P<0.05)。结论:在综合治疗基础上加用抗病毒治疗、免疫调节治疗和血浆置换治疗可显著提高慢性重型肝炎的疗效,尽早实施联合治疗可改善患者预后。

Objective; To investigate the correlation between different therapeutic measures and prognosis on patients with chronic severe hepatitis. Methods：Clinical data of 264 patients with chronic severe hepatitis were studied retrospectively. Effects of antiviral therapy, immunornodulation and plasmapheresis therapy on prognosis were analyzed statistically. Results：Antiviral therapy could significantly promote the response of patients at early and intermediate stage （P〈0. 05） immunomodulation produced a better prognosis in patients at early and intermediate stage compared with that of the control group （P〈0.05） ; plasmapheresis improved the prognosis of patients at intermediate stage （P〈0. 05）. Conclusions;Antiviral therapy, inmaunomodulation and plasmapheresis could significantly enhance the effects of treatment on chronic severe hepatitis. Early combination therapy could improve prognosis of patients.