系统性红斑狼疮伴视网膜中央动脉阻塞和脑出血1例报告及文献复习

Systemic Lupus Erythematosus Complicated With Central Retinal Artery Occlusion and Cerebral Hemorrhage:a Case Report and Review of Literatures

目的:提高对系统性红斑狼疮合并视网膜中央动脉阻塞的认识。方法:报道1例系统性红斑狼疮合并视网膜中央动脉阻塞,并且复习有关文献。结果:确诊系统性红斑狼疮合并视网膜中央动脉阻塞1例,该患者血清抗核抗体高滴度阳性,抗心磷脂抗体阳性,予以糖皮质激素、免疫抑制剂、改善微循环及对症支持治疗,期间患者出现脑出血,手术后病情稳定。结论:系统性红斑狼疮同时出现视网膜血管阻塞与脑循环障碍,提示病情严重,可能与抗磷脂抗体存在重要关联。

Objective： To improve the understanding of systemic lupus erythematosus （SLE） complicating central retinal artery occlusion. Methods： A case of SLE complicating central retinal artery occlusion was reported and discussed with literature review. Results： One case of SLE complicating central retinal artery oclusion was diagnosed. The serum antinuclear antibody CALLA） was positive in high titre and anticardiolipin antibody was positive. The patient was treated with glucoeorticoid, immunosupressant drugs, improving retinal microcirculation. Cerebral hemorrhage occurred during active therapy. The process was relived after surgery. Conclusions： SLE complicating central retinal artery occlusion and cerebral circulatory disturbance suggests that the patient＇s condition is serious and might be related to the presence of anti-phospholipid antibody.