摘要
目的:研究阿立哌唑治疗伴激越的精神分裂症患者疗效与不良反应。方法:75例伴激越的精神分裂症患者随机分为阿立哌唑组(40例)和奥氮平组(35例),治疗6周。应用阳性和阴性症状量表(PANSS)、兴奋分量表(PEC)和治疗中出现的症状量表(TESS)评定疗效及不良反应。结果:两组治疗后PANSS总分和PEC分均显著低于治疗前(P<0.05或P<0.01)。两组疗效差异无显著统计意义,两组不良反应均轻微。结论:阿立哌唑能显著改善伴激越的精神分裂症患者的症状。
Objective:To compare the effieaey and safety between aripiprazole and olanzapine in the treatment of agitated schizophrenia. Method :75 patients with agitated schizophrenia were randomly divided into two groups and then reeeived aripiprazole( n = 40) or olanzapine (n = 35 ) treatment for 6 weeks. The effi- eaey and side effects were assessed by positive and negative symptom scale( PANSS), positive exeitement cent (PEC) and treatment emergent symptom scale (TESS). Results: No significant differenee was found in the clinical effieaey ( PANSS and PEC) between aripiprazole and olanzapine in the treatment of agitated schizophre- nia for 6 weeks and the side effeets in both groups were fewer and mild. Conclusion: Aripiprazole is an effective and safe drug in the treatment of agitated schizophrenia.
出处
《临床精神医学杂志》
2009年第4期261-262,共2页
Journal of Clinical Psychiatry