白细胞介素-10和睾酮与冠心病的相关性分析

Clinical analysis of the correlation between serum IL-10 and testosterone with coronary artery disease.

目的研究血清白细胞介素-10（IL-10）及睾酮与冠心病（CHD）的关系。方法依据冠状动脉造影结果将387例患者分为CHD组239例及对照组148例，并根据冠状动脉病变支数、积分和临床病情（稳定型冠心病、不稳定型心绞痛和急性心肌梗死）将cHD组分为不同亚组；ELISA法检测血清IL-10和睾酮浓度；采用Logistic回归及偏相关方法分析IL-10及睾酮与CHD的关系。结果CHD组血清IL-10水平显著低于对照组[（39．08±14．22）．g／L与（49．27±24．67）ng／L，P〈0．001]。IL-10水平及与冠状动脉病变支数，积分和临床病情呈负相关[rs（支数）=-0．25，P〈0．001；rs（积分）：-0．25，P〈0．05；L（病情）=-0．25，P〈0．001]。血清睾酮水平在CHD组和对照组之间差异无统计学意义（P〉0．05），相关分析也未发现睾酮与CHD相关。多因素逐步Logistic回归分析提示吸烟（OR3．79，95％可信区间2．09—6．84，P〈0．01）、糖尿病（OR2．48，95％可信区间1．05～5．88，P〈0．05）、ApoB（OR14．3，95％可信区间4．29—46．61，P〈0．01）和IL-10（OR0．74，95％可信区间0．57—0．89，P〈0．01）进入模型。结论血清IL—10水平不仅与CHD的发生相关，而且与其严重程度相关，IL-10是CHD的独立保护因素。血清睾酮水平可能与CHD无关。

Objective To evaluate the correlation between seram interleukin-10 （IL-10） and testosterone with coronary heart disease （CHD）. Methods 387 patients were divided into CHD group （n =239） and control group （ n = 148 ） according to the results of coronary angiography. CHD patients were divided into subgroups according to the numbers, Gensini score of lesions in the coronary arteries and clinical severity （ statue of stable coronary artery disease, unstable angina or acute myocardial infarction）. Serum IL-10 and testosterone levels were measured by ELASA. Logistic regression and partial correlation were used to evaluate the correlation of serum IL-10 and testosterone with CHD. Results IL-10 was significantly lower in the CHD group than in the control group[ （39.08 ± 14.22） ng/L vs （49.27 ± 24.67）ng/L, P 〈 0. 001 ]. The partial correlation analysis results in subgroups showed that the correlation coefficient of IL-10 with number of lesions,gensini score and clinical severity of CHD was -0.25 ,P 〈 0.001, -0.25 ,P 〈0.05 and -0.25 ,P 〈0.001 ,respectively. Serum testosterone had no difference in control group and CHD group （P 〉 0. 05 ）. Logistic regression analysis found that only smoking （ OR = 3.79,95% CI 2.09 - 6.84,P〈0.01） ,diabetes mellitus （OR =2.48,95% CI 1.05 -5.88,P 〈0.05） ,apoB （OR = 14.3,95% CI 4.29 - 46.61 ,P 〈 0.01 ） and IL-10 （ OR = 0.74,95%, CI 0. 57 - 0.89 ,P 〈 0.01 ） entered the model. Conclusions Serum IL-10 is not only significantly correlated with CHD but also with its severity. IL-10 is an independent protective factor for CHD.