3,5-双(N-2,3-二羟丙基)乙酰胺基-N-(2-羟乙基)-2,4,6-三碘苯甲酰胺的合成

Synthesis of 3,5-bis[acetyl(2,3-dihydroxypropyl) amino]-N-(2-hydroxyethyl)-2,4,6-triiodo-benzamide

报道了新型非离子型X-CT造影剂[3,5-双(N-2,3-二羟丙基)乙酰胺基-N-(2-羟乙基)-2,4,6-三碘苯甲酰胺]的化学合成。该化合物以苯甲酸为原料,经硝化、酯化、酰胺化、还原、碘化、酰化、烷基化等制备而成。产物经元素分析、红外光谱、核磁共振谱等测定,与结构完全一致。

The synthesis of novel non - ionic X - CT contrast medium {3,5 - bis [ acetyl (2,3- dihydroxypropyl)amino] - N - (2 - hydroxyethyl) - 2,4,6- triiodo - benzamide} is reoported. This compound was synthesized through nitration, esterification, amidation, reduction, iodization, acetylation, alkylation using 3,5 -dinitrobenzoic acid as meterial. Element analysis, IR and 1 HNMR of synthetic product were conformable to the chemical structure of 3,5 - bis [acetyl (2,3 - dihydroxypropyl) amino] - N - (2 - hydroxyethyl) - 2,4,6 - triiodo - benzamide.