胃腺癌中KAI 1蛋白表达与预后的研究

The correlation between the expression of KAI1 and prognosis of patients with gastric adenocarcinoma

目的检测胃腺癌中KAI 1的表达情况,探讨其与临床病理指标及预后的相关性。方法应用免疫组织化学SP法检测接受根治性手术治疗的81例胃腺癌中KAI 1的表达情况。结果81例胃腺癌中KAI 1的阳性表达率为55.6%(45/81)。KAI 1的表达与淋巴结转移、病理学分级、临床分期有关,KAI 1蛋白表达阳性组5年生存率(55.5%)高于阴性组(22.2%),差异有统计学意义(P<0.05)。Cox模型单因素分析结果显示KAI 1蛋白表达情况对胃腺癌预后有显著影响(P<0.05),而Cox模型多因素分析结果显示KAI 1蛋白表达情况不能作为独立的预后指标(P>0.05)。结论KAI 1蛋白在胃腺癌中的表达与淋巴结转移、病理分级和临床分期有关,而与患者的年龄、性别,肿瘤的长径、浸润深度无关。蛋白表达阳性提示高生存率,可作为判断预后的辅助指标。

Objective To investigate the expression of KAI1 in gastric adenocarcinoma,and to explore the correlation between KAI1 and clinical pathological characteristics as well as prognosis.Methods The expression of KAI1 was detected by S-P immunohistochemical（IHC） staining in ESCC.Results Among the 81 cases of gastric adenocarcinoma,the positive expression rate of KAI1 was 55.6%（45/81）.KAI1 expression was not correlated with age,gender,length of tumor and depth of tumor invasion（P〉0.05）,but which was related with the metastasis of lymph node,tumor differentiation and clinical stage （ P 〈0.05 ）. The five-year survival rate of patients with positive expression of KAI1 was significantly higher than that of patients with negative expression （55.5% vs 22.2%, P 〈0.05 ）. KAII expression in well-differentiated gastric adenocarclnoma was higher than poorly-differentiated one. There was a significant negative correlation between KAI1 expression and clinical stage （ r = - 0. 38 , P 〈 0.01 ）. Univariate analysis of Cox model showed that the expression of KAI1 had obvious effect on the prognostic of patients with gastric adenocarcinoma （ P 〈 0. 05 ）, but which was not the independent prognostic indicator showed by multiplicity of Cox model （ P 〈 0.05 ）. Conclusion KAI1 expression is related with metastasis of lymph node, tumor differentiation and clinical stage. The positive expression of KAI1 suggests that patients＇ survival rate is higher, and which can be used as a reference index of ESCC.