摘要
利用RP-HPLC,以卡马西平(CZ)为内标,对国内3个厂家生产的双氯芬酸钠(D5)肠溶片进行了崩解度、释放度、含量测定的研究。结果表明:不同厂家的DS肠溶片释放度差异极为显著(P<0.01)、崩解度与释放度之间有较好的相关性(r=0.9103)。
The disintegration, release rate and assay of diclofenac sodium enteric coated tablets produced by three factories(A,B,C) in our country were determined by RP - HPLC with internal standard carbamazepine.The results showed that the difference of the release rate of different factories was very significant ( P < 0.01), the correlation between their disintegration and release rate was good(r =0.9013).
出处
《中国现代应用药学》
CAS
CSCD
1998年第3期42-43,共2页
Chinese Journal of Modern Applied Pharmacy
关键词
双氯芬酸钠
肠溶片
崩解度
释放度
相关性
dicolfenac sodium enteric coated tablet, carbamzepine, disintegration, release rate, correlation
