粉防己碱对转化生长因子β促瘢痕胶原基质收缩效应的阻断作用

Blocking Action of Tetrandrine on the Scar-Collagen Matrix Contraction Stimulated by Transforming Growth Factor β

目的 :研究粉防己碱对转化生长因子 β促瘢痕胶原基质收缩效应的作用。 方法 :将瘢痕成纤维细胞、胶原基质和转化生长因子 β共同构成体外瘢痕实验模型 ,观察粉防己碱对其收缩指数的影响。结果 :粉防己碱对转化生长因子β促瘢痕胶原基质收缩具有阻断作用 ,并呈剂量依赖关系。结论 :这一效应可能是粉防己碱抗瘢痕纤维化的机制之一。

Objective: To investigate the effect of Tetrandrine on the scar collagen matrix contraction stimulated by transforming growth factor β (TGF β). Methods: The scar derived fibroblasts were suspended in a solution of collagen matrix, and TGF β, they were associated to form a scar model in vitro. The influence of tetrandrine on the contraction indexes was observed. Results: Tetrandrine plays a blocking action in the scar collagen matrix contraction stimulated by TGF β, which was in a dose dependent manner. Conclusion: This function of tetrandrine could be responsible for the anti scar mechanism.