白细胞介素-1α-889C/T多态性与小儿癫痫易感性的关系

Association of IL-1α-889C/T polymorphism with the risk of pediatric epilepsy

目的:探讨白细胞介素-1α-889C/T多态性与小儿癫痫易感性关系。方法:采用病例对照研究,选择117例小儿癫痫患者和95例健康儿童,应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)进行IL-1α-889C/T多态性检测,比较不同基因型与小儿癫痫风险的关系。结果:与携带-889CC基因型者比较,携带至少1个-889 T等位基因者(即CT和TT基因型)小儿癫痫风险增加2.91倍(95%CI=1.27～6.69),且有癫痫或热性惊厥家族史者,-889突变型使小儿癫痫风险增加6.83倍(95%CI=2.30～20.29)。结论:IL-1α-889C/T多态性可能与小儿癫痫遗传易感性有关,并可显著增加家族史对小儿癫痫的危险性。

Objective：To explore the relationship between IL-1α-889C/T polymorphism and the susceptibility to pediatric epilepsy. Methods：IL-1α-889C/T polymorphism in 117 patients with pediatric epilepsy and 95 healthy individuals controls were analyzed with polymerase chain reaction restriction and fragment length polymorphism （PCR-RFLP）. Results： Multivariate Logistic regression analysis revealed that individuals carrying at least one -889 T variant allele （CT ＋ TT genotypes） had a significant increased risk for pediatric epilepsy （adjusted OR = 2.91,95% CI： 1.27-6.69） , compared with the wild-type genotype （-889CC） . Furthermore, individuals with epilepsy or febrile seizures family history had a significantly higher risk （adjusted OR = 6.83, 95% CI： 2.30-20.29）, compared with those with both CC genotypes. Conclusion：These findings support the hypothesis that IL-1α-889C/T polymorphism may contribute to the risk of developing pediatric epilepsy.