城市社区居民高尿酸血症与脂代谢异常的关系

Community-based research of relationship between hyperuricemia and dyslipidemia in Chinese urban residents

目的通过社区人群筛查了解国内现阶段城市居民中高尿酸血症患病率变化,同时探讨其与脂代谢异常及胰岛素抵抗的相关性。方法选择桂林市城区原住居民集中的象山社区,针对年龄在18～75岁之间居民(n=4075)采取随机横断面进行筛查。结果高尿酸血症总患病率为19.1%,男性高尿酸血症患病率为22.9%,显著高于女性高尿酸血症患病率的15.9%(P<0.001)。尿酸增高还与年龄、运动时间、食用动物油、饮酒(P<0.001)及吸烟(P<0.05)有关。血尿酸水平越高,脂代谢异常越显著,并且胰岛素水平和超敏C反应蛋白水平也越高。尿酸水平与甘油三酯、胰岛素和超敏C反应蛋白水平呈正相关(P<0.01)。尿酸增高的居民,血压、体重指数及腰围均较尿酸正常者高(P<0.01)。结论本研究发现我国社区居民高尿酸血症患病率已显著增高,与性别、年龄及生活习惯有关,高尿酸血症与脂代谢异常有相关性,高尿酸血症的增加与胰岛素抵抗有关,不良生活习惯可能是高尿酸血症、血脂异常以及胰岛素抵抗的共同风险因素。

Objective By means of community-based population screening,to detect the prevalence of hyperuricemia and its relationship with dyslipidemia and insulin resistance in Chinese,meanwhile to analysis the related risk factors of hyperuricemia. Methods 18-75 years old population（n=4 075）in the urban communities of original residents were screened by means of random cross-sectional study. Blood pressure was measured at 8-9 AM. Fasting venous blood was collected to evaluate serum uric acid（SUA） ,blood glucose, serum creatinine,serum insulin,high-sensitivity C-reactive protein （hs-CRP）,TG,TC,HDL and LDL. Resets The prevalence of hyperuricemia in the community population was 19.1% ,and the incidence was higher in men （22.9%）, compared to women （15.9%）,P〈0.001. The elevated SUA level residents were usually elderly age ,less physical activity,consume animal fat,alcohol intake（P〈0.001 ）and smoking habits（P〈0.05）. It is shown that the severity of hyperuricemia was associated with the severity of dyslipidemia, serum insulin elevation and hs-CRP when comparing between groups. The hyperuricemia residents also had higher blood pressure,body mass index （BMI）and waistline （P〈0.01）. By correlation analysis：SUA level was positively correlated with the levels of TG, serum insulin and hs-CRP（P〈0.01 ）. Conclusions It is proved by the community-based epidemic investigation that the prevalence of either byperuricemia or dyslipidemia has markedly increased in Chinese urban residents, and was associated with gender, age, and life style. It is shown that hyperuricemia was correlated with dyslipidemia. It indicated that hyperuricemia was correlated with insulin resistance,which suggests that hyperlipidemia might be a risk factor for insulin resistance and hyperlipidemia.