评估GFR的新型标志物血清胱抑素C的临床应用研究

Clinical application study of Cystatin C the new marker evaluation GFR

目的同时检测血清胱抑素C(Cystatin C,Cyst C)与内生肌酐清除率(Ccr)并进行对比分析,验证其相关性、准确性,探讨Cyst C评估肾小球滤过率(GFR)的临床实用价值。方法选择在肾脏病科住院的231例慢性肾脏病患者,其中男126例,女105例。年龄18～82岁,平均年龄48.75±18岁。应用西门子德灵诊断产品有限公司生产的BNP特定蛋白自动分析系统及试剂盒测定Cyst C,并同时检测Ccr。结果231例慢性肾脏病患者的Cyst C与Ccr呈显著负相关(r=-0.386,P<0.01),CystC随着Ccr的下降而升高,各组间比较,差异有统计学意义(P<0.01)。结论Cyst C可以单独作为评价GFR的敏感指标,比Ccr更客观地反映肾功能损伤不同时期GFR的功能。为在手术、使用造影剂、调整用药之前等急需了解肾功能状态时,提供了一个简便、准确、敏感地反映GFR的指标。

Objective To investigate clinical significance of sera level of cystatin C ,compared to Ccr,in the evaluation of glomerular filtration rate（GFR）. Methods 231 hospitalized patients（126 men and 105 women;aged from 18 to 82）with chronic kidney disease（CKD）were selected. The serum Cystain-C and Ccr were detected. Results In 231 CKD patients,serum Cystain-C is significantly correlated reversely with Ccr （r=-0.386,P〈0.01）. Ccr decreased while serum Cystain-C increased. In different 5 groups, the level of serum Cystain-C and Ccr was significantly difference （P〈0.01）. Conclusions level of serum Cystain-C is a sensitive marker that related with GFR. More objective results for evaluated GFR can be received by serum Cystain-C than by Ccr.