氨基甙类抗生素的日剂量一次给药

Once Daily Dosing Regimen for Aminoglycosides

氨基甙类抗生素日剂量一次给药是近年来研究较多的一种新给药方案，体外及动物实验表明，与常规分次给药相比，由于其抗菌后效作用和给药间隔的延长，使药物的肾、耳毒性降低。临床对照研究结果和用资料再分析法（ｍｅｔａ－ａｎａｌｙｓｉｓ）分析表明，日剂量一次给药能完全保证疗效，并使肾。

Because of the postantibiotic effect (PAE), aminoglycosides can be given once daily despite their elimination half life of two to three hours.In animal experiment, An higher but transient serum aminoglycoside level due to longer dosage interval appears to be less nephrotoxic than a lower but persistent serum concentration. Clinical trials and meta analysis suggest that the efficacy of a simplified once daily aminoglycoside dosing (ODD)is equal to that of divided dosing for gram negative infection in patients with normal renal function and that ODD may reduce the toxicity or delay it.