重症肌无力患者血清IgG-乙酰胆碱受体和突触前膜受体抗体亚型分析

Studies of the Subclasses of IgG-AchR and Presynaptic Membrane Receptor Antibodies in Patients with Myasthenia Gravis

应用ABC-ELISA法分析43例重症肌无力（MG）病人血清中IgG-乙酰胆碱受体和突触前膜受体抗体亚型。结果提示,大部分MG病人均以IgG2亚型抗体增高和IgG3亚型降低为特征;认为IgG抗体亚型的差异可能与种族有关,但未见到与临床类型相关。

The subclass analysis of IgG-AchR and presynaptic membrane receptor (PsmR) antibodies in sera of 43 patients with myasthenia gravis was done by means of ABC-ELISA studies. The results showed that most of patients were characterized by increase of IgG2 subclass and decrecse of IgG3 subclass. It suggests that the difference in IgG antibody subclasses might be related with races, but there is no any correlation with the clinical types of the disease.