不同剂量咪唑安定在纤维胃镜检查中的镇静作用

Sedation for fibreoptie gastroscopy with different doses of midazolam

目的:研究不同剂量的咪唑安定用于纤维胃镜检查的镇静作用及对呼吸和循环的影响。方法:选择104例纤维胃镜检查的患者(ASA Ⅰ～Ⅱ级),随机分为4组,N组为不用药的对照组,MS、M、D组为用药组,分别静脉注射咪唑安定0.07mg·kg^(-1)、0.05mg·kg^(-1)和安定10mg,观察镇静分级、术中症状及记忆缺失、心率、血压和血气的变化。结果:与对照组相比,用药组对胃镜检查的耐受程度明显提高(P<0.05),咪唑安定0.07mg·kg^(-1)组镇静程度、记忆缺失程度和清醒时间明显优于安定组(P<0.05),用药各组MAP在用药后1分钟下降,但无临床意义,血气分析均在正常范围。结论:咪唑安定0.07mg·kg^(-1)作为胃镜检查中镇静用药是安全有效的。

Objective: To study the effects of the different doses of midazolam in fibreoptic gastroscopy on sedation, respiratory and circulatory function. Method: One hundred and four outpatients undergoing fibreoptic gastroscopy were randomly divided into four groups. The control group(N)was not given drugs, the other groups were intravenously given midazolam 0.07mg/kg(MS),0.05mg/kg(M),diazepam 10mg(D)respectively. The sedative scores, symptom, amnesia,HR,MAP and blood gases were observed. Result: The sedative scores of MS,M and D groups were much better than that of control group. There were significant differences in sedative scores,amnesia and sedative period between MS group and D group or M group. MAP decreased one minute after administering the drugs in MS,D and M groups significantly. The results of blood gases analysis of all groups were in normal ranges. Conclusion: Midazolam 0.07mg/kg can produce safe and effective sedation for fibreoptic gastroscopy.