贞芪扶正胶囊对免疫力低下小鼠免疫功能的影响研究

Effect of Zhenqi Fuzheng Capsules on the Immune Function of Hypoimmune Mice

目的:研究贞芪扶正胶囊(ZQFZ)对免疫力低下小鼠免疫功能的影响。方法:用环磷酰胺复制小鼠免疫功能低下模型,通过测定腹腔巨噬细胞吞噬功能、迟发型超敏反应和溶血素抗体等指标,观察ZQFZ对小鼠非特异性免疫、细胞免疫和体液免疫功能的影响。结果:ZQFZ可显著促进小鼠腹腔巨噬细胞吞噬功能,提高吞噬率和吞噬指数;显著增强二硝基氯苯所致迟发型超敏反应;提高血清溶血素抗体水平。结论:ZQFZ对免疫力低下小鼠免疫功能有显著促进作用。

OBJECTIVE： To study the effect of Zhenqi fuzheng capsules（ZQFZ） on the immune function of hypoimmune mice. METHODS： The hypoimmune mice model was established using cyclophosphamid ; the effects of ZQFZ on the nonspecific immunity, cell immunity and humoral immune function of mice were observed by determining the function of peritoneal maerophage, the delayed hypersensitivity and serum antibody of hemolysin etc. RESULTS： ZQFZ significantly promoted the function of peritoneal macrophages, improved the phagocytic rate and phagocytic index, markedly enhanced the dinitro- chlorobenzene - induced delayed hypersensitivity, and upregulated the serum antibody level of hemolysin. CONCLUSION： ZQFZ have remarkable action in promoting the immune function of hypoimmune mice.