缺氧新生儿黄疸动态变化及意义

Significance and tendency of hypoxic jaundice in neonates

目的了解缺氧新生儿胆红素代谢规律，掌握临床干预的最佳时机。方法对２８１９例足月新生儿生后１～１０天进行经皮胆红素测定并分组进行比较。结果与正常新生儿相比，缺氧新生儿黄疸出现较早，上升较快，而峰值却较低，持续时间亦短，并与缺氧程度相关，差异有非常显著意义。结论重视缺氧新生儿黄疸的早期监测与干预。

Objective To study the metabolism of bilirubin in neonates with hypoxic jaundice and determine the optimal opportunity of clinical intervention. Methods Bilirubin was measurrd in 2 819 full-term neonates of 110 days of age by using transcutaneous bilirubinometry. Results Hypoxic jaundice in neonates occured at an earlier stage and developed faster than mormal neonatal jaundice. The peak values of bilirubin in neonates with hypoxic jaundice was lower, and the duration of jaundice was also shorter as compared to the normal neonates with physiological jaundice; the level of bilirubin and duration of jaundice correlated significantly with the severities of hypoxia. Conclusion Paying great attention to the early observation and intervention of hypoxic jaundice in neonates is important to prevent the central nervous system from poisoning caused by bilirubin.