重症胰腺炎35例营养支持临床研究

Clinical study of nutritional support in the treatment of patients with severe acute pancreatitis

目的:探讨重症胰腺炎患者营养支持的方法。方法:将68例重症胰腺炎患者随机分为实验组35例和对照组33例,实验组给予完全胃肠外营养支持,对照组给予主要以糖类为营养底物的支持治疗。对术后患者生化指标、并发症等进行对比分析。结果:实验组治疗5 d,10 d后血淀粉酶、转氨酶、尿素氮、白细胞、血糖等明显下降,实验组治疗后淋巴细胞总数与对照组相比有极显著性差异(P<0.01),实验组并发症发生率及病死率与对照组相比均较低(P<0.05)。结论:营养支持治疗是重症胰腺炎治疗的一项重要措施,可有效提高患者的免疫力,改善肝、肾功能,降低并发症发生率及病死率。

Objective： To study the nutritional support therapy in the treatment of patients with severe acute pancreatitis. Methods ： 68 patients with severe acute pancreatitis were randomly divided into experimental group （ n = 35 } and control group { n = 33 ）. The total parenteral nutritional support was adopted in experimental group and the nutritional support with the main substrate of carbohydrate was taken in control group. Postoperative biochemical parameters of the patients and complications were compared and analyzed. Results： In experimental group, the serum amylase, transaminase, blood urea nitrogen, WBC and blood glucose significantly decreased after treatment for 5 and 10 days, and the significant difference was found in the com- parison of the total number of lymphocytes after treatment between the two groups { P 〈 0.01 } ; the incidence of complications and mortality were lower in experimental group than that in control group { P 〈 0.05 }. Conclusion ： Nutritional support therapy can effectively improve the patient＇s immunity, liver and kidney function; reduce the incidence of complications and mortality in the treatment of patients with severe acute pancreatitis.