贵阳市甲型副伤寒沙门菌耐药性分析

On Drug Resistance Variation of Salmonella Paratyphi A Strain of Samples In Guiyang of Guizhou Province

目的了解贵阳市甲型副伤寒沙门菌的耐药状况及其变迁,为临床用药、应急药品储备及预防服药等提供依据。方法采用WHO推荐的改良K-B法,对贵阳市2000-2007年部分甲型副伤寒沙门菌进行药敏实验。结果贵阳市甲型副伤寒沙门菌对多种抗菌素耐药,合计耐药率93.2%,其中,萘啶酸耐药率最高89.0%,其次是头孢噻吩7.5%,复方新诺明、头孢噻肟和氯霉素的耐药率分别为2.7%、2.1%和1.4%。头孢噻吩的耐药率呈上升的趋势。双耐药、三重耐药及四重耐药菌株主要采集于甲型副伤寒高流行县区。结论贵阳市甲型副伤寒沙门菌存在多重耐药性,可能是其流行原因之一;耐药性日趋严重,提示药敏监测对该地区甲型副伤寒流行控制有重要意义。

Objective To study the variation of antibiotic resistance pattern of S. paratyphi A in Guiyang and provide evidence for the clinical application of antimicrobials, emergency-response drug storage and the prophylactic chemotherapy. Method One hundred and forty-six S. paratyphi A strains had been isolated and tested by K-B method on clinical samples collected from 2000 to 2007 and the antibiotic resistance was analyzed Results These strains were resistant to muhiple antibiotics and the total resistance rate was 93.2%. The resistance rate to Nalidixic acid, ceftriaxone, sulphamethoazole/trimethoprim, cefotaxime and chloram phenieol was 89.0%, 7.5%, 2. 7% 2. 1% and 1.4%, respectively. The trend of drug resistance to cefiriaxone rose from 2000 to 2007. Multi-drug resistance strains were mainly samples collected from hyper epidemic areas of Guiyang. Conclusion The results indicated that there was multiple drug resistance of S. paratyphi. A in the hyper-epidemic area of Guiyang, which might be a factor that contributed to the epidemic in the region. It suggested that drug resistance surveillance is necessary for the control of the epidemic of S. paratyphoid A fe- ver for the severity of the drug resistance in the area.