进行期寻常型银屑病患者外周血CD4^+CD25^+调节性T细胞分析

Analysis of CD4^+ CD25^+ regulatory T cells in peripheral blood of patients with psoriasis vulgaris in active stage

目的检测进行期寻常型银屑病患者外周血CD4^+CD25^+调节性T细胞(CD4^+CD25^+Treg)的水平。方法选择进行期寻常型银屑病住院患者56例和健康者16例,取外周抗凝全血,采用流式细胞术方法,检测外周血CD4^+CD25^+Treg的水平,并统计和分析其特点和意义。结果进行期寻常型银屑病患者外周血CD4^+CD25^+Treg占CD4^+淋巴细胞的比例为(2.65±0.73)%,健康对照组为(6.11±0.93)%。两组比较差异有统计学意义(P<0.001)。结论CD4^+CD25^+Treg水平降低可能与寻常型银屑病免疫学发病机制有关。

Objective To investigate the levels of CD4＋ CD25 ＋ regulatory T cells in the peripheral blood of patients with pso- riasis vulgaris in active stage. Methods Flow cytometric analysis was used to detect the percentage of CD4 ＋ CD25＋ regulatory T cells in the peripheral blood of 56 patients with psoriasis vulgaris in active stage and 16 healthy volunteers. Results The percentage of CD4＋ CD25 ＋regulatory T cells was （2.65 ＋0.73）% in patients with psoriasis vulgaris in active stage. It was （6.11 ＋0.93）% in healthy group. There was significant difference in the percentage of CD4 ＋ CD25 ＋ regulatory T cells between the two groups. Conclusion CD4 ＋ CD25 ＋ regulatory T cells may be related to the pathogenesis of psoriasis vulgaris.