SDF1-3'A多态在中国人群中的分布

The Distribution of a 3'A Polymorphism of SDF-1 Gene in a Chinese Random Population

CXCR4是嗜T型HIV－1的一个共受体，基质细胞衍生因子（Stromalderivedfactor，以下简称SDF1）是CXCR4的配体．国外最新报道SDF1基因3＇非编码区801位G→A的多态（以下简称SDF1－3＇A）与推迟爱滋病（AIDS）的发生相关．以来自中国各地区的1000个随机个体为实验对象，运用PCR－RFLP方法检测SDF1－3＇A多态，得到了SDF1－3＇A在中国人群中的基因分布频率，并观察到了中国人群中SDF1－3＇A从南至北存在明显分布差异，这为进一步进行中国人群爱滋病流行病学研究提供了实验依据．

Stromal derived factor, SDF-1, is the principal ligand for CXCR4, a co-receptor with CD4 for T-tropic HIV-1. According to the latest report from abroad, a common polymorphism, SDF1-3'A was identified in the 3' untranslated region. In the homozygous sate,SDF1-3'A/3'A delays the onset of AIDS. We applied the PCR-RFLP method on a Chinese random population of 1 000 to detect their genotypes on the SDF1-3'A site. We obtained the distribution frequencies of SDF1-3'A in the Chinese population and observed an obvious diversity of the frequencies from the south to the north. It will be served as a general background for the following HIV research work.