规范化痰诱导流程在慢性支气管炎急性发作期的应用

Application of standardized sputum induction protocol in subjects with acute exacerbation of chronic obstructive pulmonary disease

目的:探讨规范化痰诱导流程在慢性支气管炎急性加重期的应用及其安全性。方法:对40例慢性支气管炎急性加重期患者进行痰诱导,并严密监测患者的呼吸功能的变化。结果:40例患者中有38例安全渡过了整个痰诱导过程,成功率95%。40例患者在诱导结束时FEV1和SaO2均较诱导前有所下降,但在诱导结束后10 min,FEV1和SaO2均恢复至基础值水平。结论:规范化的痰诱导流程,痰诱导法对慢性支气管炎急性加重期患者是安全有效的,但在实施过程中需要严密检测患者的心肺功能。

Objective：To evaluate the safety of sputum induction in the subjects with acute exacerbations of chronic obstructive pul- monary disease.Methods：40 patients with acute exacerbation of chronic obstructive pulmonary disease were enrolled in the study. All subjects inhaled a mist of 3% hypertonic saline solution and the forced expiratory volume in one second （FEV1） and pulse oxygen satura- tion （SpO,_） were measured during the procedure.Results：A significant fall in SpO2and FEVI was found during sputum induction by in- halation of 3% hypertonic saline solution and recovered within 10 min after cessation of sputum induction. The sputum induction was suc- cessful in 38 （95%） of the 40 patients.Conclusion：The use of a standardized sputum induction protocol is relatively safe in sampling the lower airways in the patients with acute exacerbation of chronic obstructive pulmonary disease.