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肝素的抗感染作用 被引量：4

Heparin in infectious disease
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摘要 通过对肝素并结合硫酸乙酰肝素在抗感染方面的文献加以综述,总结了研究方法与研究现状,为肝素作为广谱的抗感染制剂进行药物开发提供参考。
作者 段荣帅 凌沛学 王凤山 张天民
机构地区 山东大学药学院 山东省生物药物研究院博士后科研工作站 山东商业职业技术学院
出处 《中国生化药物杂志》 CAS CSCD 北大核心 2009年第4期I0002-I0005,共4页 Chinese Journal of Biochemical Pharmaceutics
关键词 肝素 硫酸乙酰肝素 黏附 抗感染
分类号 R973.2 [医药卫生—药品]
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参考文献48

  • 1Rabenstein D L. Heparin and heparan sulfate:structure and function [J]. Nat Prod Rep,2002,19(3) :312-331.
  • 2Raman R, Sasisekharan V, Sasisekharan R. Structural insights into biological roles of protein-glycosaminoglycan interactions [ J ]. Chem Biol, 2005,12(3) : 267-277.
  • 3Lever R, Page C P. Novel drug development opportunities for heparin [J]. Nat Rev Drug Discov,2002,1(2) : 140-148.
  • 4Rostand K S, Esko J D. Microbial adherence to and invasion through proteoglycans[J]. Infect Immun, 1997,65( 1 ) : 1-8.
  • 5Spillmann D. Heparan sulfate : anchor for viral intruders? [ J]. Biochimie, 2001,83(8) :811-817.
  • 6Galan J E .The cell biology of microbial infections: coming of age[J]. J Cell Biol, 2002,158 (3) : 387-388.
  • 7Gu L, Wang H, Guo Y L, et al. Heparin blocks the adhesion of E. coli O157:H7 to human colonic epithelial cells[ J]. Biochem Biophys Res Commun,2008,369(4) :1061-1064.
  • 8Fleckenstein J M, Holland J T, Hasty D L. Interaction of an uuter membrane protein of enterotoxigenic Escherichia coli with cell surface heparan sulfate proteoglycans [ J ]. Infect Immun, 2002,70( 3 ) : 1530-1537.
  • 9Fallgren C, Andersson A, Ljungh A. The role of glycosaminoglycan binding of staphylococci in attachment to eukaryotic host cells [ J]. Curr Microbiol, 2001,43 ( 1 ) : 57-63.
  • 10Henry-Stanley M J, Hess D J, Efickson E A, et al. Role of heparan sulfate in interactions of Listeria monocytogenes with enterocytes[J]. Med Microbiol Immunol, 2003,192(2) : 107-115.

同被引文献31

  • 1赵晓东,杨锡强.肝素阻断呼吸道合胞病毒与呼吸道上皮细胞黏附作用[J].实用儿科临床杂志,2006,21(22):1540-1541. 被引量：2
  • 2黄寿吾.肝素肺内给药的研究[J].中华结核和呼吸杂志,1988,11(6):370-370.
  • 3Johnson KM, Kines RC, Roberts JN, et al. Role of heparan sulfate in attachment to and infection of the marine female genital tract by human papillomavirus [ J ]. J Virol,2009 ,83 (5) :2067 - 2074.
  • 4Guo Y,Wang Z, Dong L, et al. Ability of low -molecular -weight heparin to alleviate proteinuria by inhibiting respiratory syncytial virus infection[ J ]. Nephrology (Carlton) ,2008,13 (7) :545 - 553.
  • 5Tiwari V, O'Donnell C, Copeland RJ,et al. Soluble 3 -O- sulfated heparan sulfate can trigger herpes simplex vires type 1 entry into resistant Chinese hamster ovary ( CHO - K1 ) cells [ J ]. J Gen Virol, 2007,88 ( Pt 4): 1075 - 1079.
  • 6Bender FC, Whitbeck JC, Lou H, et al. Herpes simplex virus glycoprotein B binds to cell surfaces independently of heparan sulfate and blocks virus entry[ J]. J Virol,2005,79 ( 18 ) : 11588 - 11597.
  • 7Hallak LK, Spillmann D, Collins PL,et al. Glyeosaminoglycan sulfation requirements for respiratory syncytial virus infection [ J ]. J Virol,2000, 74(22) :10508 - 10513.
  • 8Guo Y,Wang Z,Dong L,et al. Ability of low-molecular-weight hep- arin to alleviate proteinufia by inhibiting respiratory syncytial virus infection[ J]. Nephrology(Carlton) ,2008,13 (7) :545 - 553.
  • 9Mohamed H, Caroline B. Respiratory syncytial virus in healthy a- dults:the cost ofacold[J]. JClin Vir,2003,27(1) :14 -21.
  • 10Johnson KM, Kines RC, Roberts JN, et al. Role of heparan sulfate in attachment to and infection of the routine female genital tract by hu- man papillomavirus[ J]. J Virol,2009,83 (5) :2067 - 2074.

引证文献4

二级引证文献11

中国生化药物杂志
2009年 第4期

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