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恶性胸腔积液的诊疗进展 被引量：1

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摘要 恶性胸腔积液（malignantpleuraleffusion．MPE）是恶性肿瘤晚期并发症之一。最新研究表明血管内皮生长因子（VEGF）是恶性胸水形成的关键介质。Yeh等对人肺腺癌及动物模型研究发现，恶性胸水的产生受到VEGF的调节，同时也观察到激活的Stat3（信号传导子及转录激活子蛋白）上调VEGF的表达。证实恶性胸水中存在持续激活的Stat3、高表达的IL-6和VEGF。因此他们假设自分泌IL-6激活Stat3，进而上调VEGF表达．参与恶性胸水的形成。本文就恶性胸水的诊断和治疗进展作一简要介绍：
作者 吴志丽 孙国平
机构地区 安徽医科大学附属第一医院肿瘤科
出处 《现代医药卫生》 2009年第18期2816-2818,共3页 Journal of Modern Medicine & Health
关键词 恶性胸腔积液 诊疗进展 VEGF表达 转录激活子 血管内皮生长因子 STAT3 恶性胸水 IL-6
分类号 R561.3 [医药卫生—呼吸系统] R587.1 [医药卫生—内分泌]
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参考文献18

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现代医药卫生
2009年 第18期

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