煤工尘肺患者血清一氧化氮及一氧化氮合酶水平的研究

STUDY ON NO AND NOS LEVEL IN SERUM OF CWP PATIENTS

目的:探讨血清一氧化氮(NO)及一氧化氮合酶(NOS)水平在煤工尘肺(CWP)发生发展中的意义。方法:采用硝酸还原酶法检测50名CWP患者及50名健康对照者血清NO、总NOS和iNOS水平。结果:CWP患者血清NO、总NOS和iNOS均明显高于健康人群(P<0.05);随工龄延长,CWP患者血清NO、总NOS及iNOS水平有升高趋势,但差异无显著性(P>0.05);不同期别CWP患者血清NO、总NOS和iNOS水平比较无明显差别(P>0.05)。结论:血清NO及NOS水平与煤工尘肺的发生发展有关。

Objective：To study the significance of nitric oxide （NO） and nitric oxide synthases （NOS） level in development of pneumoconiosis coal workers （CWP）.Methods：Nitrate reductase method was used to detect the NO, total NOS and iNOS level in serum of 50 CWP patients and 50 healthy people.Results：The NO, total NOS and iNOS level in serum of CWP patients were obviously higher than healthy people （P〈0.05）; Along with length of service, the NO, total NOS and iNOS level in serum of CWP patients gradually increased, but there had no obvious differences （P〉0.05）; And there also had no obvious differences between CWP patients in different stage （P〉0.05）.Condusions：The level of NO and NOS in serum has relations with development of CWP.