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5-脂氧化酶、血管内皮生长因子与乳腺癌的研究进展

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摘要 花生四稀酸(arachidonic acid,AA)是含二十碳的不饱和脂肪酸,在环氧化酶(cyclooxygenase,COX)和脂氧化酶(lipoxygenase,LOX)作用下代谢产生前列腺素(PGs)、羟基二十碳四稀酸(HETE)和白三稀(LTs)等类花生酸(eicosanoids)物质。现已证明类花生酸物质在肿瘤的发生发展和转移中起着重要作用^[1]。LOX-5是AA代谢的重要限速酶。血管内皮生长因子(vascular endothelial growth factor,VEGF)是一个特异性作用于血管内皮细胞的蛋白,是目前发现的促进新生血管形成的最重要的促进因子,
出处 《承德医学院学报》 2009年第3期315-317,共3页 Journal of Chengde Medical University
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