慢性阻塞性肺疾病与哮喘气道炎症的差异

The differences of airway inflammation between chronic obstructive pulmonary disease and asthma

慢性阻塞性肺疾病(COPD)与哮喘都是常见的慢性气道炎症性疾病,二者的气道炎症存在异同性。一些炎症细胞和肺的结构细胞如上皮细胞和内皮细胞均参与气道炎症的发生,COPD主要的炎症效应细胞是中性粒细胞,而哮喘的气道炎症以嗜酸性细胞(EOS)炎症为特征。二者参与气道炎症的细胞因子也有很大区别,在COPD主要是白介素-8(IL-8)和肿瘤坏死因子-α(TNFα-),而哮喘主要是白介素-4(IL-4)、白介素-5(IL-5)和白介素-13(IL-13)。COPD与哮喘气道炎症的差异决定二者气道炎症的本质,并可能与气流受限的不同有关。

Chronic obstructive pulmonary disease （COPD） and asthma are common chronic airway inflammatory diseases,and. they are similar and different in airway inflammation. A number of inflammatory cells and lung structural ceils such as epithelial cells and endothelial cell.s are involved in airway inflammation, the main effector cells in COPD are neutrophils, and characterized inflammatory in asthma are eosinophils （ EOS ）. Inflammatory factors that are involved in COPD and asthma are also very different. They are mainly interlukin-8 （IL-8） and tumor necrosis factor-α, in COPD, however, IL-4, IL-5 and IL-13 participated in airway inflammation in asthma. The quality of airway inflammation is decided by the difference of airway inflammation, and may be associated with the difference of airflow limitation.