转录因子在哮喘发病中的作用及靶向治疗

Function and targeted therapy of transcription factors in bronchial asthma

支气管哮喘是一种慢性炎症性疾病。大多数哮喘患者对吸入激素和β2受体激动剂治疗反应较好，然而有5％～10％的患者治疗反应欠佳。随着对哮喘分子机制的认识，研究者开始探索哮喘的靶向治疗。转录因子调节多种炎症基因的表达，并在哮喘发病中起重要作用，可能成为新的哮喘治疗靶点。

Asthma is a chronic inflammatory disease. Most asthmatic individuals respond well to the currently available treatments of inhaled corticosteroids and beta-adrenergic agonists; however,5% - 10% with severe disease respond poorly. With Improved knowledge in molecular mechanism of asthma wresearchers began to explore the targeted treatment of asthma. Transcription factors regulate the expression of muhiple inflammatory genes and play an pivotal role in asthma. Understanding transcription factors in asthma may lead to new approaches to therapy in the future.