口服斑秃丸对斑秃患者血浆内皮素水平的影响

Effects of alopecia areata pill on the serum levels of endothelin in alopecia areata patients

目的探讨斑秃与血浆内皮素的相关性及斑秃丸对斑秃患者血浆内皮素水平的影响。方法采用放射免疫法监测120例健康人血浆内皮素水平及120例不同病期(活跃期、静止期)、不同脱发面积斑秃患者口服斑秃丸后血浆内皮素水平。结果斑秃患者血浆内皮素水平明显高于健康对照组且与脱发面积显著相关;斑秃活跃期血浆内皮素水平较静止期显著增高;口服斑秃丸后血浆内皮素水平较治疗前显著下降,静止期血浆内皮素较活跃期显著下降。结论斑秃的发生、发展及病情的转归与血浆内皮素水平密切相关;斑秃丸可能通过对机体的免疫调节作用减少或抑制了血浆内皮素的产生。

Objectives To investigate the relationship between the serum levels of Endothelin （ EN ） and alopecia areata （AA）. To evaluate the effect of AA Pill on the AA patient＇s serum levels of EN. Methods The serum levels of EN of 120 healthy persons and 120 AA patients before and after AA pill treatment were measured by radioimmunoassay. Resutls The serum levels of EN in the patients of AA were markedly higher than that of the normal controls. The serum levels of EN in the patients of AA in active phase were markedly higher than those in quiescent phase. After the treatment of Alopeeia Areata Pill,the serum levels of EN were markedly decreased. The hair loss areas of the AA patients were closely related to the serum levels of EN. Conclusions The occurrence,development and outcome of AA are closely related to the serum levels of EN.