速度向量成像技术评价阿霉素致兔早期心脏损害左心室收缩同步性的变化

Velocity vector imaging evaluation of left ventricular systolic dyssynchrony in rabbits with early Adriamycin-induced myocardial damage

目的用速度向量成像技术评价阿霉素致兔早期心脏损害收缩同步性的变化,并探讨其应用价值。方法将42只兔分成4组:A、B、C组,每周一次注射阿霉素2mg/kg,分别注射2、4、8周;D组作为对照组,每周注射1次生理盐水2ml/kg,共8周。停药后2周进行超声心动图检测,获取不同切面动态图像并脱机使用VVI软件对其收缩同步性进行分析。各组兔于检查后即刻处死行心肌病理学检查。结果A组所有收缩不同步指标测值均较D组显著增高(P<0.05),B、C组测值中纵向速度指标较A组显著递增,余指标较A组有不同程度降低;仅A组出现节段间心肌收缩不同步;病理结果显示从A组到C组心肌损害逐渐加重。结论阿霉素致兔早期心脏损害可导致左心室纵向、径向、环向运动出现明显的收缩不同步现象,速度向量成像技术可用于评价早期心功能受损。

Objective To evaluate left ventricular systolic dyssynchrony in rabbits with early Adriamycin-induced myocardial damage with velocity vector imaging （VVI）. Methods Forty-two rabbits were divided into group A, B, C and D. Adriamycin was administrated in 2 mg/kg once a week for 2, 4, 8 weeks respectively in group A, B and C. In group D, rabbits were served as controls receiving the same dose of normal saline once a week for 8 weeks. Echocardiography and off-line VVI were performed two weeks after finishing of injection. Results All dyssynchrony indexes in group A were significantly higher than those in group D. The indexes of systolic velocity dyssynchrony in longitude continued rising in group B and C, but others descended inversely. Dyssynchrony among segments in all groups were of no statistical significance （P〉0. 05） except for group A. Pathological examination demonstrated that the damage severity was progressively increased from groups A to C. Conclusion The longitudinal, radial and circumferential systolic dyssynchrony of the left ventricular commonly exist in rabbits with Adriamycin-induced myocardial damage. VVI provides a simple, intuitional and noninvasive approach to assess the systolic dyssynchrony of all the LV segments simultaneously.