头花蓼化学成分的研究(Ⅰ)

Study on chemical constituents of Polygonum capitatum Buch.-Ham. ex D. Don(Ⅰ)

目的:研究头花蓼的化学成分。方法:采用反复硅胶柱层析和葡聚糖凝胶柱层析的色谱方法分离纯化头花蓼的化学成分,并根据理化性质和波谱数据进行结构鉴定。结果:从头花蓼的石油醚萃取部位分离鉴定了14个化合物,分别为二十三烷醇(Ⅰ),二十五烷醇(Ⅱ),二十二烷酸(Ⅲ),二十四烷酸(Ⅳ),十六烷酸-2,3-二羟基丙酯(Ⅴ),二十二烷酸-2,3-二羟基丙酯(Ⅵ),齐墩果酸(Ⅶ),乌苏酸(Ⅷ),二十八烷基-1,27-二烯(Ⅸ),阿魏酸二十二酯(Ⅹ),β-谷甾醇(Ⅺ),二十三烷(Ⅻ),十六烷酸(X),亚油酸(X)。结论:化合物Ⅰ～Ⅹ为从头花蓼中首次分离得到,化合物Ⅸ、Ⅹ为从蓼属中首次分离得到。

Objective：To study the chemical constituents of Polygonum capitatum. Methods：Isolation and purification of the chemical constituents were carried out repeatedly by silica gel column and Sephadex gel column chromatography. The structures of compounds were identified by physical-chemical methods and spectral data. Results：Fourteen compounds were identified from the petroleum ether fraction of P. capitatum：tricosanol （Ⅰ）,pentacosanol （Ⅱ）,docosanoic acid （Ⅲ）,lignoceric acid （Ⅳ）,hexadecanoic-2,3-dihydroxy-propyleste （Ⅴ）,docosanoic-2,3-dihydroxypropyleste （Ⅵ）,oleanolic acid （Ⅶ）,ursolic acid （Ⅷ）,octacosa-1,27-diene （Ⅸ）,docosyl ferulate （Ⅹ）,β-sitosterol （Ⅺ）,tricosane （Ⅻ）,hexadecanoic acid （ⅩⅢ）,and linoleic acid （ⅩⅣ）. Conclusion：Compounds Ⅰ-Ⅹ are obtained from P. capitatum for the first time. Compounds Ⅸ and Ⅹare obtained from Polygonum for the first time.