亚低温抑制抗脑抗体产生的相关研究

Inhibitory Effects of Mild Hypothermia Therapy on Production of Anti-Brain Antibody

目的:探讨亚低温抑制抗脑抗体产生的机制。方法:将颅脑液压创伤后的兔分成亚低温治疗组和对照组,检测0、3、7、14、21、28、35d兔血清抗脑抗体浓度和血白细胞计数并比较。结果:液压创伤后对照组血清抗脑抗体明显升高,亚低温治疗组伤后升高不明显。2组抗脑抗体血清浓度在伤后3d、7d、14d、35d比较差异具有统计学意义(P<0.05);液压创伤后对照组外周血白细胞计数3d、7d明显升高,亚低温治疗组伤后白细胞计数下降。2组白细胞计数在3d、7d、21d差异具有统计学意义(P<0.05)。结论:亚低温可能通过抑制免疫功能抑制抗脑抗体的产生。

Objective： To investigate the inhibitory effects of mild hypothermia on anti-brain antibody production and the mechanisms thereof. Methods： The rabbits of the fluid percussion model of experimental brain injury were divided into posttraumatic hypothermia-treated group and control group. The serum anti-brain antibodies and the concentration of white blood cell were tested at 0, 3, 7, 14, 21, 28, 35 d in two rabbit groups. Results： The serum anti-brain antibody after injury was significantly increased in control group. There were no significant increase in serum anti-brain antibody in the hypothermiatreated group after injury. There was significant differences in serum concentrations of anti-brain antibody at 3, 7, 14 and 35 d of two groups after injurie （P 〈 0.05）. The peripheral white blood ceil count was significantly increased at 3 and 7 d after the fluid percussion injury in control group; it was significantly decreased in hypothermia-treated group. There was a significant difference in the number of white blood cell count at 3, 7 and 21 d of two groups（P 〈 0.05）. Conclusion： The mild hypothermia may inhibit the production of anti-brain antibody by suppressing immune function.