肠内细菌对天然药物的化学修饰

Chemical Modification of Natural Drug by Intestine Bacteria

概述了目前国内外利用肠内细菌对天然药物进行生物化学修饰的研究进展情况。其中包括利用大鼠、豚鼠、家兔等试验动物及其肠内细菌对槲皮素和其糖苷芦丁、（＋）儿茶素、［４－１４Ｃ］鹰嘴豆芽素Ａ、伞形花内酯和脱肠草素、芹菜素（５，７，４三羟基黄酮）、苦杏仁苷、人参皂甙Ｒｇ１及Ｒｂ１、和厚朴酚、厚朴酚等的代谢；也包括利用人体肠内细菌对潘泻叶苷、异荭草素、当药苦苷、龙胆苦苷、桃叶珊瑚苷、京尼平苷、桅子苷、芍药苷和芍药内酯苷等的代谢方面的研究进展情况。

This paper reported that the research progress of chemical modification of natural organic compound by intestine bacteria. The contents are as follow: quercetin and its glycostine rutin, (+) catechin, 4 14 C sparteine A, umbelliprenin, apigenin, amygdalin, ginsenoside Rg 1, and honokiol and magnolol were metabolized by rat, guinea pig, rabbits and so on; and folium sennoside, swertiamarin, gentiopicroside, aucubin, geniposide, paeoniflorin, albiflorin were metobolized by human intestine bacteria.