Sox9在软骨内成骨中的研究进展

Research Progress of Sox9 in Endochondral Ossification

在胚胎发育期间，躯干和四肢骨与大部分颅面骨架均通过软骨内成骨而形成，在间充质细胞向软骨细胞、前肥大软骨细胞、肥大软骨细胞及终末分化的过程中，一系列分子信号的精密调控在正常软骨内成骨中发挥着重要作用。Sox9信号通过自身直接或间接作用，以及与其他信号共同调节软骨细胞的增殖和分化，在胚胎早期软骨内成骨中起核心调控作用。

During embryonic development, trunk,limbs and the majority of the craniofacial skeleton are growing through endochondral ossification. In mesenchymal cells into cartilage cells, pre-hypertrophie ehondroeytes, hypertrophic chondrocytes and the terminal differentiation process, a series of molecular signals play important roles in regulation of powder density within the cartilage in the normal osteoblasts. Sox9 signal not only regulates cartilage cells proliferation and differentiation in early embryonic, but also plays an important role in the early embryonic of endochondral osteoblasts.