雌激素对大鼠心内神经节IL-6和NGF表达的影响

The influence of estrogen on expression of interleukin-6 and nerve growth factor in cardiac ganglia in female rats

目的:观察白介素6(IL-6)和神经生长因子(NGF)在成年雌性大鼠、卵巢切除大鼠、卵巢切除后雌二醇替代大鼠心内神经节的表达及变化。方法:免疫组织化学方法。结果:各组大鼠心内神经节均存在IL-6阳性神经元和NGF阳性神经元,但卵巢切除组大鼠心内神经节IL-6阳性神经元明显增多,表达明显增强,而卵巢切除组大鼠心内神经节NGF阳性神经元的数量却明显减少,表达明显降低。结论:心房后壁心内神经节存在IL-6和NGF,并且受雌激素影响,提示雌二醇可能影响心内神经节IL-6和NGF的表达。

Objective：To study the expression and variance of interleukin-6 （IL-6） and nerve growth factor positive neurons in the intrinsic cardiac ganglia of females that were intact,females that were ovariectomized,or ovariectomized females that were treated with 17β-estradiol. staining technique. Results： IL-6-IR and NGF-IR neurons were presented in the intrinsic cardiac ganglia of these groups, but the number of the IL-6-IR neurons increased remarkably and their expression increased obviously in the intracardiac ganglia of ovariectomized rats, while the number of the NGF-IR neurons decreased remarkably and their expression reduced obviously in the intracardiac ganglia of ovariectomized rats. Conclusion： IL-6 and NGF are present in rat intrinsic cardiac ganglionic ceils and they are also influenced by estrogen, suggesting that 17β-estradiol may have the capacity to regulate the expression of IL-6 and NGF in intrinsic cardiac ganglia.