Ⅱ型精神分裂症急性期干预对远期阴性症状及认知功能的影响

A long-term effect of intervention during acute period on negative symptoms and cognitive function in Type Ⅱ schizophrenia patients

目的探讨在Ⅱ型精神分裂症住院期间采用脑血管扩张药"盐酸丁咯地尔"合并抗精神病药治疗对其远期临床疗效、认知功能的影响。方法将Ⅱ型精神分裂症患者共63例随机分为实验组与对照组,住院期间分别使用抗精神病药合并盐酸丁咯地尔和单纯使用抗精神病药治疗4周,于入院后第2天、入院后第4周末、出院后半年及1年采用阴性症状量表(SANS)、韦氏智力量表、韦氏记忆量表来评定患者阴性症状及认知功能的改变。结果实验组较对照组在第四周末、出院后半年SANS量表及认知功能方面差异有统计学意义(P<0.05),在出院后1年的随访中记忆量表也有明显改善。结论Ⅱ型精神分裂症住院期间采用脑血管扩展药"盐酸丁咯地尔"有助于改善其远期阴性症状及认知功能,如能长期使用效果可能更好。

Objective To study a long-term effect of antipsychotic with buflomedil hydrochlorde on the negative symptoms and cognitive function in the treatment of Ⅱ type schizophrenia patients. Methods A total of 63 Ⅱ type schizophrenic patients were divided into an experiment group and a control group in random, and treated with antipsychotic with buflomedil hydrochlorde and only antipsychotic respectively for 4 weeks. All the patients were examined in pretreatment, 4 weeks-end, half a year and one year-end by the Scale for the Aernent of Negative Symptoms （SANS）, Weehsler Adult Intelligence Scale （WAIS） and Wechsler Memory Scale （WMS）. Results In 4 weeks-end and half a year, there were significant differences in all the scale scores between the two groups. At the end of one year, only Wechsler Memory Scale showed a significant difference, P 〈 0.05. Conclusions Antipsychotic and buflomedil hydrochlorde in the treatment of Ⅱtype schizophrenia in hospital may improve the long-term negative symptoms and cognitive function.